Publications | Frisén Lab

2025

Derks W, Rode J, Collin S, Rost F, Heinke P, Hariharan A, Pickel L, Simonova I, Lazar E, Graham E, Jashari R, Andrae M, Jeppsson A, Salehpour M, Alkass K, Druid H, Kyriakopoulos CP, Taleb I, Shankar TS, Selzman CH, Sadek H, Jovinge S, Brusch L, Frisen J, Drakos S, Bergmann O

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Circulation (2025) 151(3):245-256

Classon J, Stenudd M, Zamboni M, Alkass K, Eriksson CJ, Pedersen L, Schörling A, Thoss A, Bergh A, Wikström P, Adami HO, Sørensen HT, Druid H, Frisén J

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models.

Molecular Oncology (2025) 19(11):3035-3059

de Haan S, He J, Corbat AA, Belicova L, Ratz M, Vinsland E, Frisen J, Kelley MW, Andersson ER

Ectoderm barcoding reveals neural and cochlear compartmentalization.

Science (2025) 388(6742):60-68

Dumitru I, Paterlini M, et al.

Identification of proliferating neural progenitors in the adult human hippocampus.

Science (2025)

Wu Y, Korobeynyk VI, Zamboni M, Waern F, Cole JD, Mundt S, Greter M, Frisen J, Llorens-Bobadilla E, Jessberger S

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus.

Nature Neuroscience (2025) 28(2):415-430

2024

Mold JE, Weissman MH, Ratz M, et al.

Clonally heritable gene expression imparts a layer of diversity within cell types.

Cell Systems (2024) 15(2):149-165.e10

Cell Systems PubMed

Demirci I, Larsson AJM, Chen X, Hartman J, Sandberg R, Frisen J

Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells.

Genome Biology (2024) 25(1):214

Genome Biology PubMed

2023

Derks W, Rode J, Collin S, et al.

A latent cardiomyocyte regeneration potential in human heart disease.

bioRxiv (2023) 2023.09.14.557681

von Berlin L, Westholm JO, Ratz M, Frisen J

Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis.

Hippocampus (2023) 33(4):391-401

Llorens-Bobadilla E, Zamboni M, Marklund M, et al.

Solid-phase capture and profiling of open chromatin by spatial ATAC.

Nature Biotechnology (2023) 41(8):1085-1088

Engblom C, Thrane K, Lin Q, et al.

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.

Science (2023) 382(6675):eadf8486

2022

Ratz M, von Berlin L, Larsson L, et al.

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics.

Nature Neuroscience (2022) 25(3):285-294

Stenudd M, Sabelström H, Llorens-Bobadilla E, Zamboni M, Blom H, Brismar H, Zhang S, Basak O, Clevers H, Göritz C, Barnabé-Heider F, Frisén J

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties.

Cell Reports (2022) 38(9):110440

Stenudd M, Sabelstrom H, et al.

Identification of a discrete subpopulation of spinal cord ependymal cells...

Cell Reports (2022) 38(9):110440

Classon J, Zamboni M, Engblom C, Alkass K, Mantovani G, Pou C, Nkulikiyimfura D, Brodin P, Druid H, Mold J, Frisén J

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.

Molecular Oncology (2022) 16(19):3452-3464

Classon J, Zamboni M, et al.

Prostate cancer disease recurrence after radical prostatectomy...

Molecular Oncology (2022) 16(19):3452-3464

2021

Mold JE, Modolo L, Hård J, Zamboni M, Larsson AJM, Stenudd M, Eriksson CJ, Durif G, Ståhl PL, Borgström E, Picelli S, Reinius B, Sandberg R, Réu P, Talavera-Lopez C, Andersson B, Blom K, Sandberg JK, Picard F, Michaëlsson J, Frisén J

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans.

Cell Reports (2021) 35(8):109174

Mold JE, Modolo L, Hard J, et al.

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity.

Cell Reports (2021) 35(8):109174

Dias DO, Kalkitsas J, et al.

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Nature Communications (2021) 12(1):5501

Andersson A, Larsson L, et al.

Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions.

Nature Communications (2021) 12(1):6012

Larsson L, Frisen J, Lundeberg J

Spatially resolved transcriptomics adds a new dimension to genomics.

Nature Methods (2021) 18(1):15-18

Voronina N, et al.

The age of adult pilocytic astrocytoma cells.

Oncogene (2021) 40(16):2830-2841

2020

Zamboni M, Llorens-Bobadilla E, Magnusson JP, Frisen J

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury.

Cell Stem Cell (2020) 27(4):605-617.e5

Llorens-Bobadilla E, Chell JM, et al.

A latent lineage potential in resident neural stem cells enables olfactory bulb neurogenesis.

Science (2020) 370(6512):eabb8795

Llorens-Bobadilla E, Chell JM, Le Merre P, Wu Y, Zamboni M, Bergenstråhle J, Stenudd M, Sopova E, Lundeberg J, Shupliakov O, Carlén M, Frisén J

A latent lineage potential in resident neural stem cells enables spinal cord repair.

Science (2020) 370(6512):eabb8795

Magnusson JP, Zamboni M, et al.

Activation of a neural stem cell transcriptional program in parenchymal astrocytes.

eLife (2020) 9:e59733

PubMed PubMed eLife

Santopolo G, Magnusson JP, et al.

Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke.

Cells (2020) 9(7):E1732

Mold JE, et al.

Clonally distinct differentiation trajectories shape CD8+ memory T cell heterogeneity...

BioRxiv (2020)

Floriddia EM, et al.

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury.

Nature Communications (2020) 11(1):5860

Zamboni M, Santopolo G, Frisen J

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection.

JoVE (2020)

2019

Mold JE, Reu P, et al.

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.

PLoS Biology (2019) 17(10):e3000383

Hard J, Al Hakim E, et al.

Conbase: a software for unsupervised discovery of clonal somatic mutations and genome mosaicism.

Genome Biology (2019) 20(1):68

Hård J, Al Hakim E, Kindblom M, Björklund ÅK, Sennblad B, Demirci I, Paterlini M, Reu P, Borgström E, Ståhl PL, Michaelsson J, Mold JE, Frisén J

Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing.

Genome Biology (2019) 20(1):68

Yeung MSY, Djelloul M, et al.

Dynamics of oligodendrocyte generation in multiple sclerosis.

Nature (2019) 566(7745):538-542

Weissman I, et al.

Voices: The Importance of Fetal Tissue Research.

Cell Stem Cell (2019) 24(3):357-359

2018

Salmen F, et al.

Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections.

Nature Protocols (2018) 13(11):2501-2534

Kempermann G, et al.

Human Adult Neurogenesis: Evidence and Remaining Questions.

Cell Stem Cell (2018) 23(1):25-30

Huttner HB, et al.

Meningioma growth dynamics assessed by radiocarbon retrospective birth dating.

eBioMedicine (2018) 27:176-181

Dias DO, Kim H, et al.

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

Cell (2018) 173(1):153-165.e22

2017

Borgstrom E, et al.

Comparison of whole genome amplification techniques for human single cell exome sequencing.

PLoS ONE (2017) 12(2):e0171566

Reu P, et al.

The Lifespan and Turnover of Microglia in the Human Brain.

Cell Reports (2017) 20(4):779-784

2016

Reinius B, et al.

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq.

Nature Genetics (2016) 48(11):1430-1435

Jurek A, et al.

Eph receptor interclass cooperation is required for the regulation of cell number in the intestinal stem cell lineage.

Experimental Cell Research (2016) 348(1):10-22

Jurek A, Genander M, Kundu P, Catchpole T, He X, Strååt K, Sabelström H, Xu NJ, Pettersson S, Henkemeyer M, Frisén J

Eph receptor interclass cooperation is required for the regulation of cell proliferation.

Experimental Cell Research (2016) 348(1):10-22

Vickovic S, et al.

Massive and parallel expression profiling using microarrayed single-cell sequencing.

Nature Communications (2016) 7:13182

Frisen J

Neurogenesis and Gliogenesis in Nervous System Plasticity and Repair.

Annual Review of Cell and Developmental Biology (2016) 32:127-141

Magnusson JP, Frisen J

Stars from the darkest night: unlocking the neurogenic potential of astrocytes in different brain regions.

Development (2016) 143(7):1075-1086

Stahl PL, Salmen F, et al.

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.

Science (2016) 353(6294):78-82

2015

Ernst A, Frisen J

Adult Neurogenesis in Humans--Common and Unique Traits in Mammals.

PLoS Biology (2015) 13(1):e1002045

Bergmann O, Spalding KL, Frisen J

Adult Neurogenesis in Humans.

Cold Spring Harbor Perspectives in Biology (2015) 7(7):a018994

Djelloul M, et al.

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models.

Stem Cell Reports (2015) 5(2):174-184

Kundu P, et al.

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.

Science Translational Medicine (2015) 7(281):281ra44

Bergmann O, Zdunek S, et al.

Dynamics of Cell Generation and Turnover in the Human Heart.

Cell (2015) 161(7):1566-1575

Stenudd M, Sabelstroem H, Frisen J

Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair.

JAMA Neurology (2015) 72(2):235-237

Paul G, et al.

Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease.

Journal of Clinical Investigation (2015) 125(3):1339-1346

2014

Andersen J, Urban N, et al.

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells.

Neuron (2014) 83(5):1085-1097

Magnusson JP, et al.

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.

Science (2014) 346(6206):237-241

Yeung MSY, et al.

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain.

Cell (2014) 159(4):766-774

Ernst A, et al.

Neurogenesis in the Striatum of the Adult Human Brain.

Cell (2014) 156(5):1072-1083

Huttner HB, et al.

The age and genomic integrity of neurons after cortical stroke in humans.

Nature Neuroscience (2014) 17(6):801-803

2013

Spalding KL, Bergmann O, et al.

Dynamics of Hippocampal Neurogenesis in Adult Humans.

Cell (2013) 153(6):1219-1227

Bostrom P, Frisen J

New Cells in Old Hearts.

New England Journal of Medicine (2013) 368(14):1358-1360

Sabelstrom H, Stenudd M, et al.

Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury.

Science (2013) 342(6158):637-640

Bergmann O, Frisen J

Why Adults Need New Brain Cells.

Science (2013) 340(6133):695-696

Bergmann O, Frisén J

Why adults need new brain cells.

Science (2013) 340(6133):695-696

2012

Bergmann O, et al.

Cardiomyocyte Renewal in Humans.

Circulation Research (2012) 110(1):e17-e18

Goritz C, Frisen J

Neural Stem Cells and Neurogenesis in the Adult.

Cell Stem Cell (2012) 10(6):657-659

Bergmann O, et al.

The Age of Olfactory Bulb Neurons in Humans.

Neuron (2012) 74(4):634-639

2011

Goritz C, et al.

A Pericyte Origin of Spinal Cord Scar Tissue.

Science (2011) 333(6039):238-242

Berg DA, et al.

Dopamine Controls Neurogenesis in the Adult Salamander Midbrain in a Sex-Specific Manner.

Cell Stem Cell (2011) 8(4):426-433

Bergmann O, et al.

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover.

Experimental Cell Research (2011) 317(2):188-194

2010

Seidel S, et al.

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha.

Brain (2010) 133(Pt 4):983-995

Bernard S, Frisen J, Spalding KL

A mathematical model for the interpretation of nuclear bomb test derived 14C incorporation in biological systems.

Nuclear Instruments & Methods in Physics Research Section B (2010) 268(7-8):1295-1298

Arner E, et al.

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology.

Diabetes (2010) 59(1):105-109

Forsberg M, et al.

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.

PNAS (2010) 107(33):14657-14661

Nomura T, et al.

EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells.

Cell Stem Cell (2010) 7(6):730-743

Genander M, et al.

Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle.

Stem Cells (2010) 28(7):1196-1205

Hara Y, et al.

Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice.

Stem Cells (2010) 28(5):974-983

Barnabe-Heider F, et al.

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord.

Cell Stem Cell (2010) 7(4):470-482

Ehm O, et al.

RBPJkappa-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus.

Journal of Neuroscience (2010) 30(41):13794-13807

2009

Genander M, et al.

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression.

Cell (2009) 139(4):679-692

Nomura T, Frisen J

EphB/ephrin-B signaling controls differentiation plasticity of adult neural stem cell niche cells.

Neuroscience Research (2009) 65:S101

Bergmann O, et al.

Evidence for Cardiomyocyte Renewal in Humans.

Science (2009) 324(5923):98-102

Carlen M, et al.

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Nature Neuroscience (2009) 12(3):259-267

Lindstrom S, et al.

High-density microwell chip for culture and analysis of stem cells.

PLoS ONE (2009) 4(9):e6997

2008

Spalding KL, et al.

Dynamics of fat cell turnover in humans.

Nature (2008) 453(7196):783-787

Barnabe-Heider F, et al.

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation.

Nature Methods (2008) 5(2):189-196

Duinsbegen D, et al.

Induced pluripotency with endogenous and inducible genes.

Experimental Cell Research (2008) 314(17):3255-3263

Yumoto N, et al.

Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells.

PLoS ONE (2008) 3(10):e3322

Meletis K, et al.

Spinal cord injury reveals multilineage differentiation of ependymal cells.

PLoS Biology (2008) 6(7):e182

2007

Simon A, Frisen J

From stem cell to progenitor and back again.

Cell (2007) 128(5):825-826

Falk A, et al.

High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells.

Stem Cells (2007) 25(6):1539-1545

2006

Williams C, et al.

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment.

Experimental Cell Research (2006) 312(10):1798-1812

Holmberg J, et al.

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.

Cell (2006) 125(6):1151-1163

Otal R, et al.

Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampus.

Neuroscience (2006) 141(1):109-121

Carlen M, et al.

Genetic visualization of neurogenesis.

Experimental Cell Research (2006) 312(15):2851-2859

Bhardwaj RD, et al.

Neocortical neurogenesis in humans is restricted to development.

PNAS (2006) 103(33):12564-12568

Meletis K, et al.

P53 suppresses the self-renewal of adult neural stem cells.

Development (2006) 133(2):363-369

Nomura T, et al.

Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5.

Development (2006) 133(7):1335-1345

2005

Spalding KL, et al.

Age written in teeth by nuclear tests.

Nature (2005) 437(7057):333-334

Holmberg J, et al.

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.

Genes & Development (2005) 19(4):462-471

Spalding KL, et al.

Retrospective birth dating of cells in humans.

Cell (2005) 122(1):133-143

2002

Falk A, Frisen J

Amphiregulin is a mitogen for adult neural stem cells.

Journal of Neuroscience Research (2002) 69(6):757-762

Cassidy R, Frisen J

Embryonic stem cells: Taming the fountain of youth.

Current Biology (2002) 12(20):R705-R706

Carlen M, et al.

Functional integration of adult-born neurons.

Current Biology (2002) 12(7):606-608

Falk A, et al.

Gene delivery to adult neural stem cells.

Experimental Cell Research (2002) 279(1):34-39

2001

Meletis K, Frisen J

Have the bloody cells gone to our heads?

Journal of Cell Biology (2001) 155(5):699-702

2000

Holmberg J, et al.

Regulation of repulsion versus adhesion by different splice forms of an Eph receptor.

Nature (2000) 408(6809):203-206

1999

Pekny M, et al.

Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin.

Journal of Cell Biology (1999) 145(3):503-514

Johansson CB, et al.

Identification of a neural stem cell in the adult mammalian central nervous system.

Cell (1999) 96(1):25-34

Johansson CB, et al.

Neural stem cells in the adult human brain.

Experimental Cell Research (1999) 253(2):733-736

1997

Deckner ML, et al.

Apoptotic death of olfactory sensory neurons in the adult rat.

Experimental Neurology (1997) 143(1):132-140